Design and Optimization in Organic Synthesis (Volume 8) (Data

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Design and Optimization in Organic Synthesis (Volume 8) (Data Handling in Science and Technology, Volume 8)

This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques.

The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.

The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.
Country USA
Manufacturer Elsevier Science
Binding Hardcover
UnitCount 1
EANs 9780444892010
ReleaseDate 0000-00-00

Country	USA
Manufacturer	Elsevier Science
Binding	Hardcover
UnitCount	1
EANs	9780444892010
ReleaseDate	0000-00-00

Design and Optimization in Organic Synthesis (Volume 8) (Data Handling in Science and Technology, Volume 8)

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