Filaggrin: Basic Science, Epidemiology, Clinical Aspects and

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Filaggrin: Basic Science, Epidemiology, Clinical Aspects and Management

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.
Country USA
Brand Springer
Manufacturer Springer
Binding Hardcover
ItemPartNumber 78 black & white illustrations, 82 colou
ReleaseDate 2014-06-24
UnitCount 1
EANs 9783642543784

Country	USA
Brand	Springer
Manufacturer	Springer
Binding	Hardcover
ItemPartNumber	78 black & white illustrations, 82 colou
ReleaseDate	2014-06-24
UnitCount	1
EANs	9783642543784

Filaggrin: Basic Science, Epidemiology, Clinical Aspects and Management

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